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Phenacetin 

Product Name: Phenacetin 

Synonyms: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE 

CAS: 62-44-2 

MF: C10H13NO2 

MW: 179.22 

EINECS: 200-533-0 

Product Categories: Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs 

mp  133-136 °C(lit.)

bp  132 °C / 4mmHg 

storage temp.  2-8°C

form  powder

Water Solubility  0.076 g/100 mL 

Sensitive  Hygroscopic 

Merck  14,7204 

BRN  1869238 

Stability: Stable. Incompatible with strong oxidizing agents, strong acids. 

Chemical Properties white crystalline powder 

Usage Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens. 

Glycosylation inhibitor 

Uses:

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.

Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research